Cefazolin as second line treatment for invasive Methicillin-Susceptible Staphylococcus aureus infection in a UK cohort of patients

Worldwide, cefazolin is one of the most commonly used antibiotics, as revealed in a recent article this Journal, 1 Thamlikitkul V. Rattanaumpawan P. Sirijatuphat R. Wangchinda W. Integrated one-day surveillance antimicrobial use, consumption, resistance, healthcare-associated infection, and resistance burden among hospitalized patients Thailand. J Infect. Jul 2020; 81: 98-106 Abstract Full Text PDF PubMed Scopus (4) Google Scholar but until recently has had limited availability United Kingdom. We became interested using treatment invasive Methicillin-susceptible Staphylococcus aureus (MSSA) infections, particularly bloodstream infections (BSI). Accumulating evidence suggests better tolerated than anti-staphylococcal penicillins (e.g. flucloxacillin, nafcillin, oxacillin), 2 Weis S. et al. Cefazolin versus for with bacteraemia. Clin Microbiol 2019; 25: 818-827 (51) ,3 Eljaaly K. Alshehri Erstad B.L. Systematic review meta-analysis safety antistaphylococcal compared to cefazolin. Antimicrob Agents Chemother. Mar 27, 2018; 62: e01816-e01817 Crossref (32) equally efficacious BSI due MSSA, 4 Schweizer M.L. Comparative effectiveness nafcillin or vancomycin methicillin-susceptible bacteremia. BMC Infect Dis. Oct 19, 2011; 11: 279 (183) ,5 McDanel J.S. oxacillin Methicillin-Susceptible complicated by bacteremia: nationwide cohort study. 1, 2017; 65: 100-106 (74) may improve outcomes MSSA BSI. 6 Allen J.M. anti-Staphylococcal infection: trial sequential analysis. Dis Ther. Dec, 8: 671-686 (5) ,7 Bidell M.R. Patel N. O'Donnell J.N Optimal bacteraemias: penicillins. 73: 2643-2651 (21) submitted successful application our local therapeutics committee use an unlicensed agent.